摘要
①目的 探讨大Y染色体与不良妊娠之间的关系。②方法 常规制备外周血淋巴细胞染色体G显带标本 ,对 6 0 6例检测者进行染色体核型分析。③结果 检出异常核型 5 0例 ,其中 2 2例为大Y染色体 ,大Y染色体检出率为 3.6 3% ,占异常核型的 4 4 .0 0 % (2 2 / 5 0 )。携带者配偶不明原因反复自然流产发生率为 81.82 % (18/2 2 ) ,子代颅脑神经系统发育异常发生率为 13.6 4 % (3/ 2 2 ) ,不明原因连续死胎发生率为 4 .5 5 % (1/ 2 2 )。
Objective To study the relationship between big Y chromosome and infaust pregnancy. Methods Blood samples from 606 persons examined were cultured, processed, G-stained and analyzed routinely. Results An abnormal karyotype was detected in 50 cases, in which, 22 were big Y, the incidence was 3.63%, accounting for 44.00%(22/50) in abnormal karyotype. The incidence of repeated spontaneous abortion of unknown origin of the wives of big Y carriers was 81.82%(18/22), they gave birth children with brain abnormality was 13.64%(3/22), and successive fetal death 4.55%(1/22). Conclusion The big Y chromosome has a certain genetic effect.
出处
《齐鲁医学杂志》
2003年第3期303-304,共2页
Medical Journal of Qilu
