过渡型CK19阳性表达细胞——一种新的可能的肝癌前病变的标志

Transitional" CK19 positive cells - a new possible marker of hepatic precancerous lesion

目的 探讨慢性乙型肝炎患者肝组织过渡型CK19阳性表达细胞与肝癌前病变变的关系。方法 用LSAB免疫组化染色方法观察慢性乙型肝炎患者肝组织CK19的表达,并对患者每3个月检查B超和血清AFP,随访至1年。结果 肝组 织出现卵圆细胞分化为肝细胞的过渡型CK19阳性表达细胞的患者大多数出现血清AFP的明显升高,随访至1年,有1例患者出现小肝癌,1例出现肝实质低回声结节。结论 过渡型CK19阳性表达细胞可作为一种新的可能的肝癌前病变的病理学标志。

Objective To investigate the relationship between 'Transitional' CK19 positive cells and hepatic precancerous lesion in chronic hepatitis B patients. Methods To observe the expression of CK19 in liver tissue of chronic hepatitis B patients by LSAB immuno-histochemstaining, and examine serum AFP and ultrasonography every 3 months for one year. Results We observed a population of CK19 positive cells-with size and structure between those of human oval cells and mature hepatocytes-that usually occurred along with oval-cell proliferation. It was possible that these transitional cells may partly account for the elevation of serum AFP. One patients occurred hepato-cancinoma, another patients had low-echogenic nolude in liver parenchyma in one year periodic follow-up. Conclusion ' Transitiional' CK19 positive cells could be regarded as a new possible pathological marker of hepatic precancerous lesion.