腹腔化疗治疗晚期消化道恶性肿瘤的临床评价

Evaluation of intraperitoneal chemotherapy in stage IV gastrointestinal cancer

目的 对照研究49例Ⅳ期消化道恶性肿瘤的腹腔化疗和全身静脉化疗,观察并评价两种治疗方法的近期疗效、毒副反应和远期疗效。方法 随机分为腹腔化疗组(腹腔组)28例和静脉化疗组(对照组)21例,记录观察毒副反应,随访患者并计算生存期。结果 近期疗效两组相仿,毒副反应中恶心呕吐、骨髓抑制症状,腹腔化疗组明显低于对照组,而腹胀、腹痛则腔组重于对照组,肝肾功能损害两组差异无显著性;腹腔组中位生存期和1年生存率显著高于对照组。结论 对Ⅳ期消化道恶性肿瘤患者进行腹腔内化疗可提高生存质量,延长生存期。

Objective To evaluate the short term and long term therapeutic effects of intraperitoneal versus intravenous chemotherapy in 49 cases with stage IV gastrointestinal cancer. Methods The patients were randomly divided into two groups: 28 cases in the intraperito-neally treated group and 21 cases in the intravenously treated group. The short tem effects and side effects were observed. The survival time of the patients was also recorded. Results There was no significant difference between the two groups in short term effects, and liver and kidney damages. Nausea, vomiting and bone marrow suppression were more severe in the intravenously treated group, while abdominal distension and pain were the major side effects in the intraperitoneally treated group. The median survival time and one year survival rate of patients in intraperitoneally treated group were higher than those in the intravenously treated group. Conclusion For patients with stage IV gastrointestinal cancer, intraperitoneal administration of chemotherapeutic agents is a better treatment of choice.