脐带血减缓放疗病人的骨髓功能抑制

Umbilical cord blood improve inhibitory effect of marrow function for patients undergoing radiotherapy

目的 利用脐带血减缓放疗病人的骨髓功能抑制。方法 32例放疗中外周血自细胞计数减少的病人,接受脐带血输注各一次,观察外周血白细胞计数和饮食、睡眠、无力感等临床指标。46例使用粒细胞集落刺激因子者作为对照。结果所有的病人外周血白细胞计数均有不同程度的改善。输注前WBC计数均数:(3.06±0.29)×10~9个/L,输注后均数:(4.95±0.63)x10^9个/L,配对样本t检验t值17.443,双侧P<0.001。与使用吉粒芬者相比,WBC上升幅度略小,独立样本t检验t值2.032,双侧P值0.046。输注脐带血前后睡眠变化无意义,前后饮食、无力感变化有意义,Kappa值分别是:0.833、0.020、0.380。双侧McNemar检验P值分别是:1.000、0.004、0.001。未观察到皮疹、黄疸、腹泻等急性移植物抗宿主病临床反应。结论 脐带血输注缓解放疗病人骨髓功能抑制是合理、有效、可行的。

Objective Infusion of umbilical cord blood improve inhibitory effect of marrow function for patients undergoing radiotherapy. Methods 32 cases of lack white blood cell carcinoma patients undergoing radiotherapy were infused one unit of umbilical cord blood. Their counts of white blood cells (WBC) in periphery blood, appetite, sleep and incapable feeling were observed. And the control group is 46 cases of lack white blood cell carcinoma patients who were injected granulocyte colony-stimulating factor. Results All patient's counts of WBC rose variously. The average counts of WBC before infusion is (3.06±0.29)×109/L, after infusion: (4.95±0.63)×109/L, paired samples T test t value: 17.443, double tail P < 0.001. Compared with the control group, the scope of WBC rising less. Independent sample T test t value is 2.032, double tail P = 0.046. Before an after infusion, their sleeping varied slightly, their appetite and incapable feeling were improved obviously. Kappa value is below: 0.833、.020、0.380; double McNemar test p value is as below: 1.000、0.004、 0.001. The signs of eruption, jaundice and diarrhoea about acute graft versus host disease were not observed. Conclusion Infusion of umbilical cord blood improving inhibitory effect of marrow function for patients undergoing radiotherapy is reasonable, effective and feasible.