益生元对饮用银化水模拟失重大鼠骨代谢与骨生物力学的影响

Effects of prebiotics on bone metabolism and bone biomechanics in simulated weightless rats treated with silverionzed drinking water

目的 研究饮用银化水对模拟失重大鼠骨代谢与骨生物力学的影响及益生元的调整作用。方法 40只SPF级SD雄性大鼠随机分为地面对照组 (GC)、模拟失重对照组 (SC)、模拟失重饮用银化水组 (SS)、银化水与益生元模拟失重组 (SPS) ,实验期 2 1d。EDTA滴定法测定饲料钙表观吸收率和骨钙含量 ,双能X射线测右侧股骨密度 ,质构仪测右侧股骨生物力学指标。结果 骨代谢指标SC组显著低于GC组 (P <0 0 0 1 ) ,SS组也低于SC组 (P <0 0 5) ,SPS组高于SS组 (P <0 0 5) ;SC组骨结构力学和材料力学指标均显著低于GC组 (P <0 0 0 1 ) ,SS组材料力学指标低于SC组 (P <0 0 5) ,SPS组材料力学指标高于SS组 (P <0 0 5)。结论 饮用 0 2 0mg/L银化水加重了模拟失重大鼠骨代谢的紊乱和骨材料力学的下降 ,而益生元可以缓解饮用银化水模拟失重大鼠骨代谢的紊乱和骨材料力学的下降。

Objective To study the effects of silverionized water on the bone metabolism and bone biomechanics in simulated weightless rats, and the effects of prebiotics on simulated weightlessness and drinking silveronzed water in rats Methods Forty male SD rats were randomly divided into ground control group(GC), simulated weightlessness control group(SC),simulated weightless group treated with silverionized water (SS),and simulated weightless group treated with silverionized water and prebiotics (SPS) The apparent absorption of calcium in food and the BMD, BMC,bone biomechanics of right femur were measured Results The BMD, BMC and bone biomechanics of group SC were significantly lower than those of group GC, and those of group SS were lower than those of group GC, and those of group SPS were higher than those of group SS Such were the cases with the material properties; besides, the struetural propenties of group SC were also significantly lower than that of group GC Conclusion Silverionized water has a negative effect on the bone metabolism and material properties in the simulated weightless rats, and prebiotics has a positive effect on those in the simulated weightless rats treated with silverionized water