105例Ⅱ型糖尿病患者骨密度变化的分析

Analysis of variation of BMD in 105 patients with type 2 diabetes mellitus

目的 研究Ⅱ型糖尿病患者骨密度的变化规律和临床特点 ,更深入了解糖尿病对骨代谢的影响。方法 使用双能X线骨密度测定仪测定 1 0 5例Ⅱ型糖尿病患者腰椎L1 ～L4 、Ward’s三角区、股骨颈、股骨大转子区的骨密度 (BMD) ,并以同年龄、同性别的健康者的骨密度比较 ,研究其骨密度的变化规律和临床特点。结果 ①女性Ⅱ型糖尿病患者BMD测定值与同年龄对照组比较差异无显著性。②男性Ⅱ型糖尿病患者BMD测定值除了 51～ 60岁年龄组差异有显著性外 ,61岁以上年龄组差异无显著性。③男性Ⅱ型糖尿病患者BMD测定值明显高于同年龄的女性。各年龄组Ward’s三角区BMD测定值明显低于腰椎和股骨颈及股骨大转子区。结论 ①雌激素水平下降是绝经后妇女骨质疏松的主要原因。②Ⅱ型糖尿病能使部分老年患者易患有骨质疏松症。

Objective To further understand an effect of diabetes on metabolism of bone, we investigated the rule of variation of BMD and clinical features of the patients with Ⅱ type diabetes Methods By detecting the value of BMD in lumbar vertebyae (L 1 L 4),neck of femur, greater trochanter of femur in 105 cases of patients with Ⅱ type diabetes using Dual energy X ray absorptiometry (DEXA) We also detected the value of BMD in healthy with the same age and the same sex as control group Results 1, There is no obvious difference of the detected value of BMD between the female patients with Ⅱ type diabetes and the control group with the same age 2, There is obvious difference of the detected value of BMD in male patients with Ⅱ type diabetes at 51 60 year group And there is no obvious difference in the group that is beyond 61 years 3, The detected value of BMD in male patients with Ⅱ type diabetes is obvious higher than that in female patients at the same age The detected value of BMD in the Ward's triangular zone is obvious lower than that in lumbar vertebrae, neck of femur, greater trochanter at every age group Conclusions 1, The decrease of oestrogenic hormone level is the main reason of osteoporosis in the postmenopausal women 2, The Ⅱ type diabetes could cause osteoporosis in some aged patients 3,The variation of value of BMD in osteoporosis at first appears in the Ward's triangular zone