肝内移植猪胰岛细胞治疗1型糖尿病4例临床报告

Intrahepatic Transplantation of Porcine Islet to Four Patients with Type 1 Diabetes

目的 探讨经肝动脉植入猪胰岛细胞治疗 1型糖尿病的临床效果。方法 4例病人接受肝动脉插管移植新生猪胰岛细胞。观察移植前后胰岛素用量、空腹血糖 (FBS)、餐后血糖 (PBS)、糖化血红蛋白 (HBA1)及肝肾功能变化。结果 4例病人移植前FBS 7 4～ 13 5mmol/l,PBS 7 8～ 18 6mmol/l,HBA17 8～ 12 %。移植后观察 1年半左右 ,FBS波动在 3 3～ 7 1mmol/l,PBS为 6 0～8 8mmol/l,HbA1为 6 8～ 7 6% ,胰岛素量减少 3 2 %～ 5 8% ,肝肾功能及肝脏影像学检查未见异常。结论 经肝动脉植入猪胰岛细胞治疗

Objective To investigate the clinic effect of trans-artery intrahepatic transplantation of porcine islet in type 1 diabetic patients. Methods Four patients with type 1 diabetes were perfused newborn porcine islets through the hepatic artery.Fasting blood glucose(FBS), postprandial blood glucose (PBS), HBA1,dose of insulin and function of liver and kidney were measured before and after the transplantation.Results The levels of FBS,PBS and HBA1 were 7 4～13 5mmol/L,7 8～18 6mmol/L and 7 8～12 0mmol/L respectively before the transplantation. During one and half years after transplantation, the levels of FBS,PBS and HBA1 were 3 3～7 1mmol/L,6 0～8 8mmol/L and 6 4～7 6mmol/L respectively with notably reduced dosage of insulin(32～58%).The function of liver and kidney of the patients remained normal.Conclusions Trans-artery intrahepatic transplantation of porcine islet is effective and safe for type 1diabetic treatment.