癫痫患者智能状况与脑脊液γ-氨基丁酸的相关性研究

A Study of Relationship Between Intelligence Condition of the Epileptic Patient and γ-GABA in CSF

目的 探讨癫痫患者智能状况与脑脊液γ -氨基丁酸 (CSF -GABA)含量的关系。方法 采用韦氏智力量表对 40例癫痫患者进行智商测定 ,应用高效液相色谱法 (HPLC)测定其CSF -GABA含量 ,并对影响癫痫患者智能的因素进行分析。结果 40例癫痫患者中总智商FIQ≤ 89者 14例 ,占 3 5 %。癫痫患者智能状况主要与CSF -GABA含量、文化程度、发作类型呈正相关 ,与患者年龄呈负相关。其中以CSF -GABA含量对VIQ、PIQ、FIQ影响作用明显 (P <0 0 1,P <0 0 5 )。且癫痫病人智能障碍组CSF -GABA含量明显低于智能正常组 (P <0 0 1)。结论 CSF -GABA含量在一定程度上能反映癫痫患者智能状况 ,为临床判断。

Objective To explore the relationship between the intelligence condition and the content of γ-aminobutyric acid (GABA) in cerebrospinal fluid (CSF) in epileptic patients.Methods We measured the Intelligence Quotient (IQ) of 40 cases of epileptic patients by using the Wechsler Intellectual Scaled, and tested their CSF-GABA contents by using HPLC.At the same time, factors which might have influence on patient’s IQ were analysed.Results In the 40 cases of epileptic patients, there were 14 cases of patients with FIQ≤89, and occupied 35%.The intelligence condition of epileptic patients was positive relation with the contents of CSF-GABA, education background and patterns of seizure,but was negative relation with the patient's age. Among all factors, content of CSF-GABA was very significant relationship with VIQ, PIQ and FIQ (P<0 01,P<0 05). CSF-GABA content in the group of intelligence disturbance patients was significantly lower than that in the group of normal intelligence patients.Conclusion The content of CSF-GABA could reflect in some degree the intelligence condition of the epileptic patient,which may provide us with objective evidence for clinical judgement, treatment and prevention of intelligence disturbance in epileptic patients.