前列腺素E_1对高血压性肾损害早期肾小管的保护作用

The Protective Effect of Prostaglandin E_1 on Renal Tubules of Early Stage Hypertensive Renal Damage

目的 探讨前列腺素E1对高血压性肾损害早期肾小管的保护作用。方法 将 45例属于高血压性肾损害早期患者分为常规治疗组和PGE1治疗组 (常规治疗加用PGE1治疗 ) ,常规治疗组采用钙拮抗剂和ACE抑制剂 ,PGE1治疗组的PGE1用量为10 μg/d静脉滴注。于第 2周末观察两组尿α1-微球蛋白 (α1-MG)、尿NAG酶和 2 4h尿蛋白定量。结果 经 2周治疗后 ,两组 2 4h尿蛋白定量均较治疗前下降 ,但尿α1-MG和尿NAG酶仅在PGE1治疗组有显著降低 ( P <0 0 1)。

Objective To investigate the protective effect of prostaglandin E 1 on renal tubules of early stage hypertensive renal damage.Methods Forty-five patients were divided into two groups:Common treatment group who were treated with anti-hypertensive drugs,which were calcium channel blocking agents and angiotensin-converting enzyme inhibitors,and PGE 1 treatment group who were treated with both anti-hypertensive drugs and PGE 1.PGE 1 was given intravenously at dosage of 10μg per day. Two weeks after starting treatment,the urine alpha1 microglobulin(α 1-MG), N-acetyl-beta-glucosaminidase (NAG) and 24 hours total urinary proteins were examined in these two groups.Results After two week treatment, 24 hours total urinary proteins decreased in both groups, however, the urine α 1-MG, NAG decreased only in PGE 1 treatment group (P<0 01).Conclusion PGE 1 can relieve early stage hypertensive renal damage by protecting renal tubules.