2型糖尿病患者血浆TNF-α水平与胰岛素抵抗的关系

Relationship of Plasma TNF-α Levels and Insulin Resistance in the Patients with Type2 Diabetes

目的 探讨 2型糖尿病患者血浆TNF -α水平与胰岛素抵抗的关系。方法 用放免法测定 3 8例非肥胖型 2型糖尿病患者及 3 0例正常人的血浆TNF -α浓度 ,计算胰岛素敏感指数 (ISI)和体重指数 (BMI) ,并将血浆TNF -α分别与ISI、BMI做直线相关分析。结果 2型糖尿病患者血浆TNF -α水平为 3 0 79± 6 64fmol/ml,显著高于正常对照组 ,(P <0 0 0 5 ) ;糖尿病组ISI为 -5 64±0 3 5 ,而正常对照组为 -4 0 4± 0 43 ,二者有显著性差异 (P <0 0 0 1。 2型糖尿病患者血浆TNF -α水平与ISI的相关系数为 -0 67(P <0 0 0 5 ) ,呈显著负相关 ;在女性患者 ,血浆TNF -α水平与BMI呈显著正相关 ,直线回归方程为Y =1 2 19X +2 40 6,r =0 68(P<0 0 0 5 )。结论 非肥胖型 2型糖尿病患者存在胰岛素抵抗 ;非肥胖型 2型糖尿病患者血浆TNF -α水平升高 。

Object To investigate the relationship between plasma tumor necrosis factor α(TNF-α) and insulin resistance in the patients with non obese type 2 diabetes.Methods The levels of plasma TNF-α and serum insulin were measured in 38 patients with type 2 diabetes and 30 healthy subjects by immuno-radioassay. Insulin sensitive index (ISI) and body mass index(BMI) were also calculated. The correlation analysis was done between TNF-α and ISI.Results ⑴ The levels of plasma TNF-α in type 2 diabetes were 30 79±6 64fmol/ml, and higher than those in controls (P<0 005);⑵ There was a negative correlation between plasma TNF-α level and ISI(r=-0 67),and plasma TNF-α level was positively associated with BMI in female patients(r=0 68).Conclusions The level of plasma TNF-α increases in patients with type 2 diabetes, and it could reflect the degree of insulin resistance indirectly.