复方黄甘颗粒对肾脏的作用机理研究

Study on Mechanism of Action of Compound Huanggan Granules on the Kidney

目的 :阐明复方黄甘颗粒的作用机理。方法 :用同位素示踪、电磁流量计技术和导尿管集尿法 ,研究复方黄甘颗粒对兔肾血流量、肾小球滤过率和利尿作用。结果 :复方黄甘颗粒能显著增加兔肾血流量、肾小球滤过率 ,具有明显的利尿作用。结论 :复方黄甘颗粒的作用机理是通过增加兔肾血流量和肾小球滤过率 ,以及利尿作用 。

OBJECTIVE:To research the mechanism of action of compound Huanggan gr anules(FHG) METHODS:To observe the effect of FHG on the renal blood flow and glomerular filtration rate,and its mechanism of diuresis by means of isotopic tracer,electromagnetic flowmeter and ureter catheterization RESULTS:FHG could significantly increase the renal blood flow and glomerular filtration rate,and enhance the diuresis CONCLUSION:Its diuresis is based on the increase of rena l blood flow and glomerular filtration rate,which results in the decrease of ne phrotoxic substances such as blood urea nitrogen and serum creatinine