沙棘果肉油对大鼠胃液分泌的影响及抗胃溃疡作用

Effects on Gastric Secretion and Anti-gastric Ulcer Action of Sea Buckthorn Pulp Oil in Rats

目的 :研究沙棘果肉油对大鼠胃液分泌的影响及其抗胃溃疡作用。方法 :以幽门结扎收集胃液 ,观察对胃液分泌的影响 ;采用大鼠水浸应激性、利血平型、幽门结扎型及乙酸型胃溃疡模型研究沙棘果肉油抗胃溃疡作用 ;以热板法和扭体法观察其镇痛作用。结果 :沙棘果肉油能抑制大鼠胃酸及胃蛋白酶的分泌 ,促进胃粘液的分泌 ;对大鼠水浸应激性、利血平型、幽门结扎型胃溃疡均有明显的保护作用 ;对大鼠乙酸型胃溃疡有明显的促进愈合作用 ;可减少小鼠的扭体次数。结论 :沙棘果肉油有抑制实验性胃溃疡的作用,该作用可能与其抑制胃酸分泌、促进胃粘液分泌及镇痛作用有关。

OBJECTIVE:To study the effects on gastric secretion and anti-gastr ic ulcer action of sea buckthorn pulp oil(SBPO)in rats METHODS:The effects of SB PO on gastric secretion in rats were studied with pylorus ligation The anti-ga stric ulcer actions of SBPO was observed on the gastric ulcer models induced by water immersion stress,reserpine,pylorus ligation or acetic acid The analgesi c effect was tested by the hot-plate method and writhing method RESULTS:SBPO significantly inhibited the secretion of gastric acid and pepsin and promoted th e secretion of gastric mucus SBPO markedly protected the formation of gastric u lcer induced by water immersion stress,reserpine or pylorus ligation and promot ed the healing of acetic acid induced gastric ulcer SBPO significantly decrease d the number of twisting body in mice CONCLUSION:SBPO has anti-gastric ulcer effect The mechanisms of anti-gastric ulcer action might be its effects of inh ibition of the secretion of gastric juice,promotion of the secretion of gastric mucus and analgesic effect