摘要
目的 观察伊维菌素和阿苯达唑伍用治疗肠道线虫感染的效果。方法 采用国产伊维菌素伍用阿苯达唑(6mg+200mg)(14岁以下儿童剂量减半)分别治疗蛔虫、钩虫、鞭虫、蛲虫感染者,同时用阿苯达唑400mg治疗钩虫、鞭虫感染者、用伊维菌素12mg治疗钩虫、蛲虫感染者作为对照。结果 伊维菌素伍用阿苯达唑治疗蛔虫、钩虫、鞭虫、蛲虫感染者的虫卵阴转率分别为100.00%(30/30)、86.67%(26/30)、88.24%(30/34)和97.62%(41/42);阿苯达唑对照组钩虫和鞭虫的虫卵阴转率分别为70.58%(24/34)和47.06%(16/34),伊维菌素对照治疗组钩虫、蛲虫虫卵阴转率分别为46.15%(12/26)和57.14%(16/28)。伊维菌素伍用阿苯达唑的不良反应发生率低而轻,对血象、肝肾功能和心电图无明显影响。结论 国产伊维菌素伍用阿苯达唑治疗钩虫、鞭虫、蛲虫感染效果显著,对鞭虫疗效明显优于阿苯达唑,对钩虫、蛲虫疗效明显优于伊维菌素,并且有排虫快、不良反应少而轻等优点。
Objective To observe the efficacy of ivermectin combined with albendazole for treatment of intestinal nematode infec-tions. Methods A single dose of ivermectin 6 mg combined with albendazole 200 mg (half dose by year under 14) was given to treat persons who were infected with ascaris, hookworm, trichuris and Enterobius vermicularis, and single dose of albendazole 400 mg was given to treat the persons who were infected with hookworm. trichuris, single dose of ivermectin 12 mg was given to treat the persons who were infected with hookworm and E. vermicularis as control. Results The ascaris, hookvvorm, trichuris and en-terobius eggs negative conversion rates of ivermectin combined with albendazole were 100. 00%(30/30), 86. 67%(26/30) , 88. 20% (30/34) and 97. 62% (41/42); The hookvvorm, trichuris eggs negative conversion rates of albendazole were 70. 59% (24/34) and 47. 06%( 16/34); the hookworm, enterobius eggs negative conversion rate of ivermectin were 46. 15%(12/26) and 57. 14%(16/ 28). The side effect was mild and transient, and it had no adverse effect on blood picture, liver or renal function and ECG. Conclu-sion There was satisfaction effect against ascaris, hookworm, trichuris and E. vermicularis, using ivermectin 6 mg combined with albendazole 200 mg. The drugs were characteristic of quick worm-expelling efficacy, and seldom side effect.
出处
《中国寄生虫病防治杂志》
CSCD
2003年第4期214-216,共3页
Chinese Journal of Parasitic Disease Control