联用帕罗西汀治疗难治性精神分裂症临床观察

Clinical Observation in Treatment-refractory Schizophrenia with a Combination of Antipsychotics and Paroxetine

目的 :观察抗精神病药联用小剂量帕罗西汀治疗难治性精神分裂症阴性症状的疗效和不良反应。方法 :对35例难治性精神分裂症病人在原有抗精神病药物治疗的基础上 ,加用帕罗西汀 2 0 mg。采用简明精神病学量表 (BPRS)、阴性症状量表 (SANS)和不良反应症状量表 (TESS) ,于联合用药前和联用后 2、4、8周末 ,分别进行评分。并同时检查血、尿常规及生化、心电图。结果 :35例病人均完成 8周的治疗。按研究结束时 SANS减分率判定 ,无效 15例 (42 .9%) ,有效16例 (45 .7%) ,显效 4例 (11.4%)。联合用药 8周后 ,BPRS、SANS总分及其中几项因子分均比合用前显著降低 (P <0 .0 5或 0 .0 1) ,而 TESS评分联合用药前后无显著性差异 (P>0 .0 5 )。结论 :抗精神病药物联用小剂量帕罗西汀 ,可改善难治性精神分裂症病人的阴性症状 ,且少有不良反应。

Objective: To observe the efficacy and side effects of a combination of antipsychotics and Paroxetine in the treatment of negative symptoms in treatment-refractory schizophrenia. Method: 35 patients were treated with Paroxetine 20mg combined with antipsychotics. BPRS, SANS, TESS were used to evaluate the efficacy and side effects before and after treatment respectively. Results: Total scores of BPRS and SANS significantly decreased after treatment in the group of antipsychotics combined with Paroxetine, and TESS score was not significantly higher. Conclusion: A combination of antipsychotics and Paroxetines can remarkably improve negative symptoms in schizophrenia and produce fewer side effects.