γ-干扰素治疗慢性乙型肝炎肝纤维化的临床疗效

The clinical effect of interferon- γ on liver fibrosis caused by chronic hepatitis B

目的 以常规治疗做对照,观察应用注射用重组人γ-干扰素(IFN-γ)治疗慢性乙型病毒性肝炎肝纤维化的临床疗效。方法 慢性乙型病毒性肝炎患者,随机分配入IFN-γ治疗组和常规治疗对照组,治疗前、治疗3个月和6个月进行肝纤维化血清学指标、B超检查,并观察不良反应。结果 入组41例慢性乙型病毒性肝炎患者,用药6个月后,IFN-γ治疗组较常规治疗对照组肝纤维化血清学指标明显下降,未观察到严重副作用。结论IFN-γ有一定的抗肝纤维作用。

Objective To observe the clinical effect of interferon- r (IFN- r) on liver fibrosis caused by chronic hepatitis B. Methods Chronic hepatitis B patients were randomized to IFN- y treatment group and control group.Serum fibrotic markers and ultrasonography were done before and after treatment. Results Forty one cases were enrolled. Serum fibrotic markers in IFN - r treatment group decreased significandy after 6 months treatment compared to the control group. No serious adverse efiects were found. Conclusion IFN - r has the effect of antifibrosis.