天蟾胶囊镇痛作用的实验研究

Experimental research of the analgesic effect of Tianchan capsule

目的 :考察天蟾胶囊对大鼠、小鼠的镇痛作用。方法 :采用小鼠醋酸扭体反应、小鼠热板法镇痛试验、大鼠甩尾法镇痛试验及对大鼠三叉神经痛的镇痛实验。结果 :天蟾胶囊能显著抑制小鼠热板、扭体反应及大鼠甩尾反应 ,提高大鼠三叉神经痛阈。给药起效时间约 30min ,作用峰值在给药后 12 0min。天蟾胶囊的镇痛效果随剂量的加大而增强 ,但该药的早期作用 (药后 15～ 6 0min)弱于阳性对照药哌替啶。结论 :天蟾胶囊对实验大鼠、小鼠具有明显的镇痛作用。

Objective:To study the effect of Tianchan capsule in animals.Methods:The analgesic effect of Tianchan capsule was studied in mice and rats using HAC writhing reaction,hot plate test,tail flick test and pain threshold measurement of trifacial neuralgia.Results:The mice response to HAC writhing reaction and hot plate test as well as the rats response to tail flick test and pain threshold measurement were significantly inhibited by Tianchan capsule.Time of onset of action was about 30 minutes after dosing, and its peak value was reached around 120 minutes.The analgesic effect of Tianchan capsule was increased with increase of dose.Conclusion:Tianchan capsule has significant analgesic effect in mice and rats.