放射治疗时间与中晚期宫颈癌预后关系的研究

Study of the relationship between the overall radiation treatment time and the advanced cervix cancer prognosis

目的 研究中晚期宫颈癌单独放疗时总的放疗时间对治疗结果的影响。方法 选择1986～1990年治疗的386例Ⅱb和Ⅲ期宫颈癌患者进行外照射和腔内照射,对这些患者进行综合分析,确定总的放疗时间是否为影响预后的因素。结果 经过综合分析表明,宫颈癌放射治疗中总的治疗时间和输血是影响疗效的两个最具有显著意义的因素。治疗时间超过56 d时,每超过1 d,局部控制率和总生存率大约每天降低1％。结论 总的放射治疗时间是影响中晚期宫颈癌疗效的预后因素。

Objective To search for possible influence of overall treatment time on the clinical outcome of advanced cervical carcinomas treated with radiation alone.Methods Three hundred and eighty- six patients with Ⅱb and Ⅲ cervical carcinomas treated with external radiation and intracavitary between 1986 and 1990 were entered in the study. A multivariate analysis was carried out on data concerning these patients to determine whether overall treatment time was a prognostic factor. Results Overall treatment time and blood transfusions during treatment were the two most highly significant factors in the multivariate analysis. Loss of local control and overall survival, when treatment time exceeded 56 days, was approximately 1 % per day in both cases. Conclusion These results suggest that overall treatment time might be a highly significant prognostic factor in the treatment outcome of advanced cervical carcinomas.Prospective randomized studies are strongly warranted to confirm this hypothesis.