茶色素对早期糖尿病肾病患者血浆GMP-140和血浆内皮素的影响

TEA PIGMENT'S INFLUENCE ON PMG-140 AND PLASMA ET FOR EARLY DIABETIC NEPHROPATHY

目的 :探讨茶色素对早期糖尿病肾病患者血浆GMP - 14 0和血浆内皮素 (ET)的影响及临床意义。方法 :6 8例早期糖尿病肾病患者随机分成对照组 (n =34)和治疗组 (n =34)两组 ,对照组采用糖尿病 (DM )常规治疗 ,治疗组在常规治疗基础上加用茶色素治疗 ,每天 3次 ,每次 0 .2 4 g口服。两组疗程均为 8周。另选取 30名正常人为健康人组。采用放射免疫法和酶联免疫吸附法分别测定健康人组、对照组与治疗组治疗前后血浆ET、2 4h尿白蛋白排泄率 (UAER)和血浆GMP - 14 0。结果 :糖尿病肾病 (DN)患者血浆ET、血浆GMP - 14 0水平显著高于健康人 (均P <0 .0 1) ,治疗组治疗后血浆ET、血浆GMP - 14 0、UAER水平分别为 70 .6± 19.7ng/L、6 8.9± 19.7μg/L、6 9.5 2± 4 0 .2 7μg/min ,较治疗前的 10 3.2± 2 6 .3ng/L、10 1.2± 39.5 μg/L、10 9.31±72 .15 μg/min明显降低 (均P <0 .0 1) ,对照组治疗后血浆ET、血浆GMP - 14 0、UAER水平分别为 98.4±2 4 .2ng/L、89.2± 35 .9μg/L、95 .35± 4 9.92 μg/min ,较治疗前的 10 1.8± 2 5 .9ng/L、98.9± 37.1μg/L、10 8.2 3±6 9.72 μg/min无明显变化 (均P >0 .0 5 ) ,治疗组治疗 8周后血浆ET、血浆GMP - 14 0、UAER较对照组显著下降 (P <0 .0 1,P <0 .0 5 ,P

Objective:Probing the influence and clinical significance of the tea pigment to the GMP-140 and ET of the early diabetic nephropathy patient.Methods:Random division of 68 cases of early DN into the contrasting group and the therapeutic group. The contrasting group was applied diabetic nephropathy ( DN )regular treatment and the therapeutic group was added to tea pigment on the basis of regular treatment. 3 times per day and being taken O. 24g every time. Both of them would be treated 8 weeks. There was another group made of 30 healthy people. Obtaining the changes of GMP-140, ET and UAER in per-post, and different group through enzyme linked immunosorbent assay and radioimmunoussay.Results:The level of plasma ET and GMP-140, taken from the ON patient, was higher than the health. The level of plasma ET and GMP-140, taken from the therapeutic group was obviously declined after having been treated( P <0. 01). The level of plasma ET and GMP-140, taken from the contrasting group, had no distinct change after having been treated ( P> 0. 05). The level of plasma ET and GMP-140, UAER, taken from the therapeutic group, was obviously declined compare with the contrasting group after taking treat of 8 weeks ( P <0.01, P <0.05, P <0.01).The decline of plasma ET was obviously parallel to decline of UAER ( P <0.01).Conclusion: The happening and development of DN maybe relate to the change about the level of plasma ET and CMP-140. The tea-pigment could reduce the DN patient/s plasma ET, GMP-140 and improve and protect the functionof kidney. It provided the theoretical basis to treat DNby using tea pigment, and made for a new way to treating DN.