胰腺癌患者围手术期血清bFGF、ColⅣ、HA的变化及意义

CHANGES AND SIGNIFICANCE OF SERUM bFGF,CoIⅣ AND HAIN PERIOPERATIVE PERIOD PATIENTS WITH PANCREATIC CANCER

目的 :探讨胰腺癌患者围手术期血清碱性纤维母细胞生长因子 (bFGF)、Ⅳ型胶原 (ColⅣ )和透明质酸(HA)的变化及其临床意义。方法 :用分别采用双抗体夹心酶联免疫法 (ELISA)和放射免疫法测定 5 8例胰腺癌患者手术前后血清bFGF、ColⅣ和HA的含量 ,并与健康对照组比较分析。结果 :胰腺癌组治疗前bFGF、ColⅣ和HA均增高 ,与对照组比较有显著性差异 (P <0 .0 1) ;且与淋巴结转移和肿瘤临床TNM分期有明显相关性。行根治性手术组术后bFGF、ColⅣ和HA均有显著性降低 (P <0 .0 1) ,而姑息性手术组bFGF、ColⅣ和HA则无显著性降低 (P >0 .0 5 )。结论 :胰腺癌患者血清bFGF、ColⅣ和HA的变化与肿瘤的浸润转移和病程有关 ,检测胰腺癌患者血清bFGF、ColⅣ和HA的变化 ,有助于估计患者的预后。

Objective:To investigate the changes of serum bFGF, ColⅣ and HA in patients with pancreatic cancer before and after operation, and evaluate their clinical significance.Methods:The contents of serum bFGF, ColⅣ and HA in 58 patients with pancreatic cancer were detected by ELISA and radioimmunoassay respectively befor and after opreration and compared them with that of health controls. Results:The contents of serum bFGF, ColⅣ and HA in the patients with pancreatic cancer befor operation were significantly higher than that in control group( P <0.01).there was significant correlation between the contents to lymph node metastasis and clinical stage (TNM) The contents of bFGF,ColⅣ and HA were significantly decreased in patients with pancreatic cancer after radical resection ( P <0.01).But there was not significant decrease of the contents of bFGF, ColⅣ and HA in patients with pancreatic cancer after palliative operation ( P >0.05).Conclusion:The contents of serum bFGF, ColⅣ and HA are closely related to tumor invasion, metastasis and clinical stage (Duke' s).Dynamic determination of the contents of serum bFGF, ColⅣ and HA may be an important index for evalution of invasion, metatasis, efficiacy and progrosis for the patients with pancreatic cancer.