降钙素原在肾移植术后并发细菌感染中的临床应用

CLINICAL APPLICATION OF PROCALCITONIN IN KIDNEY TRANSPLANTATION WITH BACTERIAL INFECTION

目的 :探讨降钙素原 (PCT)在肾移植术后并发细菌感染诊断中的临床意义。方法 :采用免疫层析法检测肾移植患者血清中的PCT浓度。结果 :肾移植术后并发细菌感染时患者血清中PCT浓度增高 ,发生急性排斥反应时不增高 ,二者之间的差异有显著性意义 (P <0 .0 1) ;发生急性排斥反应患者与无并发症患者血清PCT浓度之间的差异无显著性意义 (P >0 .0 5 ) ;随着感染的控制 ,PCT浓度逐渐下降至正常水平 ,若感染不能控制 ,PCT浓度将继续维持在可检测水平。结论 :PCT的检测可为肾移植术后并发细菌感染的诊断 ,及其和急性排斥反应的鉴别诊断提供有效的实验室依据。

Objective:To study the application of procalcitonin (PCT) in diagnosis of bacterial infection in kidney transplanted patients.Methods:PCT was measured in serum samples of kidney transplanted patients using an immuno-chromatografic assay.Results: PCT elevated markedly in patients suffering from bacterial infection, but not in patients suffering from acute rejection, the statistical difference between PCT levels in bacterial infection and acute rejection was significant( P <0.01); PCT levels for patients with rejection did not differ significantly from those of the healthy transplant recipients ( P >0.05); PCT levels declined gradually to normality with the control of in fection, or maintained at the level that can be detected when the infection had not be controlled.Conclusions:The detection of PCT can provide laboratory information for diagnosis of bacterial infection in kidney transplanted patients, and for identification of bacterial infection and acute rejection.