Graves病患者血清sCTLA-4测定及临床意义

Expression of sCTLA-4 in Sera from Patients with Graves Disease.

目的 研究Graves病患者血清中sCTLA—4表达及与甲状腺自身抗体TPO—Ab、TG—Ab和甲状腺激素FT3、FT4相关性在Graves病发病中的作用。方法 以ELISA ABC—HRP法测定sCTLA—4;以ELISA双抗法规定TPO—Ab、TG—Ab;以电化学发光法测定FT3、FT4。结果 实验组sCTLA—4水平与对照组相比明显升高(P<0.01),但与TPO—Ab、TG—Ab相关性不显著(P>0.05,P>0.05),与FT3、FT4亦无明显相关性(P>0.05,P>0.05)。结论 sCTLA—4可能在Graves病的发病机理中发挥重要作用,但作用机制似与甲状腺自身抗体TPO—Ab、TG—Ab及甲状腺激素FT3、FT4无关。

Objective To study the expression of sCTLA-4 and its association with TPO-Ab, TG -Ab, FT3, FT4 in patients with Graves disease. Methods ELISA and ELECSYS were used for the detection of sCTLA- 4, TPO-Ab, TG-Ab and FT3, FT4. Results The level of sCTLA-4 was remarkably increased (P < 0, 01) in sera from patients with Graves disease but significant association of sCTLA -4 with TPO-Ab, TG-Ab, FT3, FT4 was not observed. Conclusions The results suggest that sCTLA-4 may play an important role in Graves disease, but it seems that the effect of sCTLA-4 has no remarkable relation to the TPO-Ab, TG-Ab, FT3, FT4.