抗帕颗粒对血管性帕金森综合征患者血液流变学及甲襞微循环的影响

Effect of Anti-Parkinson Potion on Hemorrheology and Nail Wall Microcirculation in Patients with Vascular Parkinsonism

目的 :研究抗帕颗粒对血管性帕金森综合征 (VP)患者血液流变学及甲襞微循环的影响。方法 :对照组36例 ,单用美多巴 ,研究组VP患者32例在美多巴治疗的基础上加用抗帕颗粒 ,分别检测加药前、后第7 ,15 ,30d血液流变学、甲襞微循环的各项指标。结果 :研究组使用抗帕颗粒第7d后,除红细胞压积外 ,所有血液流变学及甲襞微循环指标与对照组相比均有显著性差异。血液流变学指标到第15d继续下降 ,直至第30d(P<0.01) ;甲襞微循环各项指标第7d达最低 (P<0.01) ,一直延续至第30d(P<0.05)。结论 :抗帕颗粒可明显改善VP血液流变学及甲襞微循环 ,达到病因干预的目的。

Objective:To study the effect of anti-Parkinson potion(APP)on hemorrheology and nail wall microcirculation in patients with vascular Parkinsonism(VP).Methods:The patients with VP were divided into a treatment group(n=32)and a control group(n=36)randomly.The treatment group was received by APP oˉrally with fundamental madopar therapy,the control group with only madopar,Every parameter of hemorrheolˉogy and nail wall microcirculation before and the7th,15th,30th day after treatment was detected.Results:In the control group,all parameters did not changed remarkably.In the treatment group,all parameters except erythrocyte expressing volume of hemorrheology changed remarkably after the7th day,distinctively lower than those of the control group,and went on declininged to the30th(P<0.01);every parameter of nail wall microˉcirculation decreased at the7th(P<0.01),and last to the30th day(P<0.05).Conclusion:APP can obviously improve the hemorrheology and nail wall microcirculation of VP patients,and so it can interfere with etiological factors.