摘要
小鼠原始生殖细胞产生于原肠胚形成阶段 ,迁移到生殖嵴位置后获得性别分化决定。体外培养时原始生殖细胞可大量增殖 ,现在已经建立了人类EG细胞株 ,这些永生的EG细胞具有正常的核型和多向分化能力 ,它可分化为某些特定的细胞类型 。
The germ cell lineage in the mouse is established during gastrulation;sex determination is achieved after germ cell migrating to the site of the future gonads. Germ cells proliferate indefinitely when cultured in vitro . Human embryonic germ(EG) cells have been recently established;these immortalized EG cells are chromosomally stable and pluripotent, raising the hope that their differentiation can be directed to specific cell types, which may be of value in the clinical treatment of degenerative diseases.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第9期960-962,共3页
Academic Journal of Second Military Medical University
基金
国家杰出青年科学基金 ( 3 982 5 116)
海外青年学者合作研究基金 ( 3 992 80 0 9)
