摘要
Oct4是一种POU转录因子 ,属于Ⅴ类POU蛋白 ,在小鼠全能胚胎干细胞和生殖系干细胞表达。在早期鼠胚中 ,只有在ICM变成滋养层阶段 ,Oct4为维持其全能表型而发挥作用。Oct4表达可能是由位置效应引起的 ,还与特异调节Oct4活性的元件 ,如近端、远端增强子元件有关。Oct4对转录的调节分为抑制转录和转录激活两种。Oct4的激活有 3种模式 :远端依赖性共激活 ,构象依赖性共激活 。
The Oct4,a POU transcription factor belongs to class Ⅴ of POU proteins, is expressed in mouse totipotent embryonic stem and germ cells. Oct4 plays a critical role in maintaining pluripotency of stem cell when it differentiates into a trophectoderm lineage at early stage of mouse embryo. Oct4 expression appears to be regulated by a positional effect as well as specific regulating elements of Oct4 such as proximal enhancer (PE) and distal enhancer (DE). Oct4 has both repression and activation effects in regulating transcription,and the activation has 3 models: distance dependent transactivation, conformational transactivation and Oct4 dimers dependent transactivation.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
2003年第9期963-965,共3页
Academic Journal of Second Military Medical University
基金
国家杰出青年科学基金 ( 3 982 5 116)
海外青年学者合作研究基金 ( 3 992 80 0 9)
关键词
OCT4
胚胎干细胞
全能性扩增
研究进展
Oct4
embryonic stem cell
totipotent proliferation
review literature