期刊文献+

卡培他滨治疗晚期大肠癌22例

下载PDF
导出
摘要 目的:评价卡培他滨单药治疗晚期大肠癌的疗效及毒副作用。方法:22例晚期大肠癌患者给予卡培他滨2 500 mg·(m2)-1·d-1,po,连用2周,每3周为1个周期,常规6-8周期,有严重毒副作用者需停药或减量。结果:肿瘤完全缓解(CR)2例,部分缓解(PR)6例,稳定(SD)10例,进展(PD)4例。主要不良反应为手足综合征(36.4%),经调整剂量可缓解。结论:卡培他滨单药治疗晚期大肠癌疗效确切,安全性较高,可作为晚期大肠癌的一线治疗药物。
出处 《医药导报》 CAS 2003年第10期693-694,共2页 Herald of Medicine
  • 相关文献

参考文献6

  • 1贾宝辉,史成章.新型选择性肿瘤化疗药物──卡培他滨[J].国外医学(药学分册),2002,29(5):282-286. 被引量:10
  • 2Ishikawa T, Utoh M, Sauada N, et al. Tumor selective delivery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts[J]. Biochem Pharmacol, 1998,55(7): 1091 -1097.
  • 3Schuller J, Gassidy J, Dumont E, et al. Preferential activation of capecitabine in tumor following oral administation to colorectal cancer patients[J]. Cancer Chemother Pharmacol, 2000,45(4):291-297.
  • 4Hoff P M, Ausari R, Batist G, et al. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as tirst-line treatment in 605 patients with metastatic colorectal cancer results of a randomized phase Ⅲ study[J]. J Clin Oncol , 2001,19(8):2282-2292.
  • 5Van Cutsem E, Twelves C, Cassidy J, et al. Oral capecitabine compared with intravenous fluorouracil plus leucovorin in patients with metastatic colorectal cancer results of a large phase Ⅲ study[J]. J Clin Oncol,2001,19(21) :4092 - 4106.
  • 6Maroun J A. Capecitabine in the management of colorectal cancer[J]. Exp Rev Anticancer Ther, 2001,32(1):327-333.

二级参考文献27

  • 1Takebayashi Y, Akiyama S, Akiba S, et al. Clinicopathologic and prognostic significance of an angiogenic factor, thymidine phosphorylase, in human colorectal carcinoma[J]. JNatl CancerInst, 1996, 88(16):1110- 1117.
  • 2Tsukamoto Y, Kato Y, Ura M, et al. Investigation of 5-FU disposition after oral administration of capecitabine, a tripleprodrug of 5-FU, using a physiologically based pharmacokinetic model in a human cancer xenograft model: comparison of the simulated 5-FU exposures in the tumour tissue betwcen human and xenograft model[J]. Biopharm Drug Dispos, 2001, 22(1): 1-14.
  • 3Ishikawa T, Utoh M, Sawada N, et al. Tumor selective dehvery of 5-fluorouracil by capecitabine, a new oral fluoropyrimidine carbamate, in human cancer xenografts [J].Biochem Pharmacol, 1998, 55(7): 1091-1097.
  • 4Ishikawa T, Sekiguchi F, Fukase Y, et al. Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts[J]. Cancer Res, 1998, 58(3) :685-690.
  • 5Ishikawa T, Fukase Y, Yamamoto T, et al. Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5-deoxy-5-fluorocytidine (capecitabine) [J]. Biol Pharm Bull, 1998, 21(7) :713- 717.
  • 6Schuller J, Gassidy J, Dumont E, et al. Preferential activation of capecitabine in tumor following oral administration to colorectal cancer patients[J]. Cancer Chemother Pharmacol, 2000, 45(4) :291-297.
  • 7Reigner B, Verweij J, Dirix L, et al. Effect of food on the pharmacokinetics of capecitabine and its metabolites following oral administration in cancer patients[J]. Clin Cancer Res, 1998, 4(4) :941-948.
  • 8Reigner B, Clive S, Cassidy J, et al. Influence of the antacid Maalox on the pharmacokinetics of capecitabine in cancer patients [J]. Cancer Chemother Pharmacol , 1999,43(4) :309-315.
  • 9Twelves C, Glynne-Jones R, Cassidy J, et al. Effect of hepatic dysfunction due to liver metastases on the pharmacokinetics of capecitabine and its metabolites[J]. Clin Cancer Res, 1999, 5(7): 1696-1702.
  • 10Poole C, Gardiner J, Twelves C, et al. Effect of renal impairment on the pharmacokinetics and tolerability of capecitabine (Xeloda) in cancer patients [J]. Cancer Chemother Pharmacol, 2002, 49(3) :225-234.

共引文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部