应用疏肝舒乳颗粒治疗乳腺增生症间接人体组织病理学对照研究

The indirect contrast study of human histopathology applying Shu Gan Shu Ru to treat the hyperplastic disease of breast

目的 探讨疏肝舒乳颗粒 (SGSR)对乳腺增生症 (HDB)的形态学影响。方法 随机选取HDB标本 6 6例 ,治疗和未治疗组各 33例 ,进行光学显微镜组织结构对比研究。HDB依组织增生程度的不同被分为四级 (0～III)。结果 治疗后 ,HDB增生及异型增生的腺上皮回复正常或萎缩消失 ,同未治疗组相比 ,有极显著的统计学差异 (P <0 .0 1)。结论 SGSR不仅能够抑制乳腺导管上皮和小叶的增生 ,还能使其发生退行性改变 ,甚至萎缩消失。SGSR可作为治疗HDB和预防乳癌发生的药物。

Objective To study the morphologic influence of Shu Gan Shu Ru (SGSR) on hyperplastic disease of breas(HDB). Methods 66 cases of HDB were randomey selected, the treated and untreated 33 cases respectively, tissue slides were observed by using microscopy. The 66 cases of HDB were divided into four degrees(0～III). Results After treatment, the epithelia of proliferation and hyperplasia returned normal or atrophic disappeared and there were statistically striking differences( P < 0.01 ). Conclusion SGSR can not only restrain the hyperplasia of duct epithelia and lobules of breast but also made atrophic change. Therefore SGSR can be used as a drug of treating HDB and preventing breast carcinoma.