伊曲康唑与环吡酮联合治疗严重甲真菌病疗效观察

Clinic Efficacy and Safety of ltraconazole Combined with Ciclopirox for Severe Onychomycosis

目的 :探讨口服伊曲康唑与外涂 8%环吡酮循序联合治疗严重甲真菌病的疗效及安全性。方法 :随机将 6 7例严重甲真菌病患者分为 2组 ,治疗组 35例 ,口服伊曲康唑间歇冲击与外涂 8%环吡酮甲涂剂循序联合治疗 ;对照组 32例 ,用 2 0 %乙酸溶液代替 8%环吡酮甲涂剂与伊曲康唑循序联合应用。结果 :在冲击治疗结束时 ,两组的治愈率、有效率及真菌转阴率没有差异。冲击治疗后 3月、6月及治疗结束后 3月 ,两组的临床总治愈率及有效率比较有显著性差异 (P <0 0 5 ) ,但真菌学阴转率比较无显著性差异 (P >0 0 5 )。结束治疗后 3个月时对照组临床复发 1例。结论 :口服伊曲康唑间歇冲击与外用 8%环吡酮甲涂剂联合治疗可作为严重甲真菌病首选方案之一。

Objective:To evaluate the clinic efficacy and safety of itraconazole combined with ciclopirox for severe onychomycosis.Methods:67 patients with severe onychomycosis were divided into 2 groups randomly,the treatment group (35 patients) were given on intermittent treatment of itraconazole,then the ciclopirox was used on topical and the control group (32 patients) were orally itraconazole only and acetic acid on topical. Results:There were no statistic difference between the two groups after treatment of itraconazole, but there were a significantly statistic difference on both cure rate and effective rate between the two groups after 3, 6 or 9 months of the combined therapy (P<0.01～0.05),there were still no difference on fungi negative rate (P>0.05) between these two groups.There was only one patient was recurrence in control group. Conclusion:Itraconazole combined with ciclopirox was one of the best choices for severe onychomycosis.