26例儿童系统性红斑狼疮临床分析

The Clinical Investigation of Systemic Lupus Erythematosus in 26 Children Cases

目的 :探讨儿童系统性红斑狼疮 (SLE)的临床及实验室检查特点及其与病程的关系 ,方法 :回顾性分析 2 6例住院儿童SLE的临床及实验室检查结果 ,统计分析其发病率及与病程的关系。结果 :儿童SLE以发热、面部红斑、关节痛、全身乏力为主要临床表现 ,发生率分别为 1 0 0 %、96 2 %、92 3%和84 6 %。血清免疫学检查中ANA阳性率最高 (84 6 % ) ,其次为Sm抗体 ,(4 2 3% )。胸片提示 34 6 %的患者有肺部感染。在病程≤半年组与病程 >半年组间各项临床表现及实验室检查的异常发生率均无统计学差异 ,P >0 0 5。结论 :病程的长短对儿童SLE的影响尚需进一步按不同的时间段进行分组研究。对儿童SLE应加强抗感染治疗。

Objective:To investigate the clinical and laboratory characteristics and their relationships with the course of systemic lupus erythematosus(SLE) in children and to guide clinical practice.Methods: The clinical onsets and laboratory results of 26 hospitalized children with SLE were retrospectively analyzed. The incidence rates were measured and their relationships with the course were statistically analyzed. Results:The main clinical onsets of children with SLE were fever、erythema on faces、arthralgia and generalized seizure and the incidence rates were 100%、96.2%、92.3% and 84.6%, respectively. The highest positive rate of serum immunology was ANA(84.6%), the next was Sm(+)(42.3%). 34.6% patients showed lung infection by the chest X-ray examination. No significant differences were recognized in the clinical onsets and abnormal experimental marks between the groups of less or equal to 1/2 year and more than 1/2 year coursos(P>0.05). Conclusion: the role of course in children SLE should be further studied according to different courses. Anti-infection treatment should be strengthened in children SLE.