佛手和枸杞提取物对小鼠皮肤胶原蛋白、SOD含量及毛发生长的影响

Effects of the Extract from Bergamot and Boxthorn on the Delay of Skin Aging and Hair Growth in Mice

目的 :研究佛手和枸杞提取物对小鼠皮肤和毛发生长的作用。方法 :将佛手和枸杞提取液涂抹于小鼠脱毛皮肤部位 ,观察涂抹部位毛发生长情况 ,42d后取涂抹部位皮肤 ,测定超氧化物歧化酶SOD活性、胶原蛋白和丙二醛的含量。结果 :与空白对照组比较 ,佛手和枸杞提取液都能显著提高小鼠皮肤中SOD的活性 (P <0 .0 5) ,增加皮肤中胶原蛋白的含量 (P <0 .0 0 1 ) ,明显减少脂质过氧化产物丙二醛的含量 (P <0 .0 5) ,促进毛发的生长 (P <0 .0 0 1 )。结论

Objective:To study the effects of the extract from bergamot and boxthorn on the skin and the hair growth in mice. Method:The skin on the back of mice was shaved topically and smeared with bergamot and boxthorn extract for 42 days. Then the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) and collagen in the mice were measured. The growth of hair was also observed. Result:Compared with control group, the extract from bergamot and boxthorn obviously increased the activity of superoxide dismutase ( P <0.05) and the content of collagen ( P <0.001), and decreased the content of malondialdehyde ( P <0.05) in the skin of mice. It also significantly promoted the growth of hair( P <0.001). Conclusion:The extract from bergamot and boxthorn plays an active role in skin and the promotion of hair growth.