长链脂酰CoA与胰岛素抵抗
摘要
胰岛素抵抗(IR)是2型糖尿病的主要特征,长链脂肪酸在脂质诱导的IR中起重要作用。血浆游离脂肪酸增多可以导致组织内脂质聚集,长链脂酰CoA和甘油三酯含量升高,这些代谢产物一方面通过影响胰岛素信号转导,使参与糖脂代谢的关键酶活性丧失;另一方面对特异性核转录因子表达进行调控,造成葡萄糖代谢的改变和β细胞功能紊乱,最终导致IR。
出处
《国外医学（内分泌学分册）》
2003年第5期302-304,共3页
Foreign Medical Sciences(Section of Endocrinology)
参考文献17
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