融合基因PAX3/PAX7-FKHR研究进展
摘要
腺泡型横纹肌肉瘤 (ARMS)具有特征性的染色体易位t(2 ;13)或t(1;13) ,分别形成PAX3 FKHR和PAX7 FKHR融合基因 ,改变了相关野生型蛋白的表达、功能和亚细胞定位 ,通过调节生长、分化和凋亡等途径促进肿瘤发生。融合基因的不同产物可能预示不同的预后。PAX3/PAX7 FKHR是高度特异和灵敏的遗传标记 。
出处
《国外医学（生理病理科学与临床分册）》
2003年第4期383-385,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献20
-
1Chi N, Epstein JA. Getting your Pax straight: Pax proteins in development and disease[J]. Trends Genet, 2002,18( 1 ) : 41-47.
-
2Fitzgerald JC, Scherr AM, Barr FG. Structural analysis of PAX7 rearrangements in alveolar rhabdomyosarcoma [ J ]. Cancer Genet Cytogenet, 2000,117 ( 1 ) : 37-40.
-
3Barr FG. The role of chimeric paired box transcription factors in the pathogenesis of prdiatric rhabdomysarcoma[ J ]. Cancer Res, 1999,59(Suppl 7) :S1711-S1715.
-
4Bennicelli JL, Advani S, Schafer BW, et al. PAX3 and PAX7 exhibit conserved cis-acting transcription repression domains and utilize a common gain of function mechanism in alveolar rhabkomyosarcoma [ J ]. Oncogene, 1999,18 ( 30 ) : 4348-4356.
-
5del Peso L, Gonzalez VM, Hemandez R, et al. Regulation of the forkhead transcription factor FKHR, but not the PAX3-FKHR fusion protein, by the serine/threonine kinase Akt[J]. Oncogene, 1999,18(51 ) :7328-7333.
-
6Anderson J, Ramsay A, Goukd S, et al. Pax3-ikhr induces morphological change and enhances cellular proliferation and invasion in rhabdomyosarcoma[ J]. Am J Pathol, 2001,159 ( 3 ) : 1089-1096.
-
7Fredericks WJ, Ayyanathan K, Herlyn M, et al. An engineered PAX3-KRAB transcriptional repressor inhibits the malignant phenotype of alveolar rhabdomyosarcoma cells harboring the endogenous PAX3-FKHR oncogene[ J]. Mol Cell Biol, 2000,20(14) :5019.
-
8Armoni M, Quon MJ, Maor G, et al. PAX3/Forkhead Homolog in Rhabdomyosarcoma Oneoprotein Activates Glucose Transporter 4 Gene Expression in Vivo and in Vitro [ J ]. J Clin Endocrinol Metab, 2002, 87( 11 ) :5312-5324.
-
9Ayyanathan K, Fredericks WJ, Berking C, et al. Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKFR oncogene [ J ]. Cancer Res, 2000,60(20) :5803-5814.
-
10Margue CM, Bemasconi M, Barr FG, et al. Transcripitonal modulation of the anti-apototic protein Bcl-XL by the paired box transcription factors PAX3 and PAX3/FKHR[J]. Oncogene, 2000,19( 25 ) :2921-2929.
-
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-
2高红,欧阳玲,张可仞,张志波,王维林.横纹肌肉瘤中融合基因PAX3／PAX7-FKHR表达和染色体遗传变异[J].中华医学遗传学杂志,2007,24(1):42-47. 被引量：3
-
3李光辉,王东林.PAX3-FKHR与横纹肌肉瘤[J].重庆医学,2002,31(10):1003-1005.
-
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-
5谢仲秋,曾勇.融合基因与肿瘤[J].肿瘤药学,2014,4(6):402-404. 被引量：3
-
6李巧新,刘春霞,淳采璞,齐妍,常彬,农卫霞,姚恩生,李洪安,李锋.利用比较基因组杂交技术分析横纹肌肉瘤中染色体基因组的变化特征[J].中华病理学杂志,2008,37(8):536-541. 被引量：2
-
7高红,张志波,王维林,黄英.先天性巨结肠Pax3和Cx43基因突变及表达[J].世界华人消化杂志,2004,12(9):2254-2256. 被引量：13
-
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-
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-
10李莉,刘少扬,江大琼.基质金属蛋白酶及其抑制剂在肿瘤发展和治疗中的作用[J].肿瘤防治研究,2004,31(2):123-125. 被引量：6
