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自然杀伤细胞受体家族NKG2D研究进展 被引量：3

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摘要 NKG2D是自然杀伤细胞的一种激活性受体 ,与其配体MICA和MICB结合后 ,在多肽DAP 10P的介导下激活自然杀伤细胞 ,导致表达MHC和MICA/B分子的靶细胞被杀伤 ,在肿瘤的免疫监视中发挥重要的作用。UL16结合蛋白 (ULBPs)是NKG2D的另一种新的配体分子 。
作者 马凌娣 蒋纪恺
机构地区 重庆医科大学检验系临床生化教研室
出处 《国外医学（生理病理科学与临床分册）》 2003年第4期425-427,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
关键词 自然杀伤细胞 受体 NKG2D MIC ULBPs
分类号 R392 [医药卫生—免疫学]
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参考文献16

  • 1Wu J, An activating receptor complex on natural killer and T cell sformed by NKG2D and DAP10[J]. Science,1999,285:730-732.
  • 2Wu J,Cherwinski H, Spies T,et al. DAP10 and DAP12 form distinct, but functionally cooperative, receptor complexes in natural killer cells[J]. J Exp Med,2000,192:1059-1068.
  • 3Chang C. KAP10, a novel transmembrane adapter protein genetically linked to DAP12 but with unique signaling properties[ J]. J Immunol, 1999,163:4651-4654.
  • 4Wei S. Direct tumor lysis by NK cells uses a Ras-independent mitogen-activated protein kinase signal pathway [ J ]. J Immuno1,2000,165:3811-3819.
  • 5Jiang K. Pivotal role of phosphoinositide-3 kinase in regulation of cytotoxity in natural killer cells[ J]. Nat Immunol.2000.1:419-425.
  • 6Kane L. Andres P, Howland K,et al. Akt provides the CD28 costhnulatory signal for up-regulation of IL-2 and 1FN-r but not Th2 cytokines[J]. Nat Immunol,2001,2 :37-244.
  • 7Bauer S, Groh V, Wu J,et al. Activaton of natural killer cells and Tcells by NKG2D, a receptor for stress-inducible MICA [ J ]. Science, 1999,285:727-730.
  • 8Diefenbach A, Jamieson AM, Liu SD, et al. Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages[J]. Nat Immunol,2000,1:119-126.
  • 9Groh V,Bahram S,Bauer S,et al. Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium[J]. Proc Natl Acad Sci USA, 1996,93:12445-12450.
  • 10Cosman D. The human cytomegalovirus ( HCMV ) glycoproteinm UL16, bind to the MHC class I-related protein, MICB/PERB11,and to two novel, MHC class I-related molecules, ULBPland ULBP2[J]. FASEB J,2000,14:A1018.

同被引文献34

  • 1狄岩,张明,姜达.肿瘤化疗多药耐药性的分子机制及其干预[J].临床荟萃,2005,20(8):476-478. 被引量：3
  • 2杨玲,李连弟,陈育德,Donald Maxwell Parkin.中国肺癌死亡趋势分析及发病、死亡的估计与预测[J].中国肺癌杂志,2005,8(4):274-278. 被引量：168
  • 3丁军颖,王润田.人MICA基因多态性和表达特性与肿瘤的关系[J].现代免疫学,2007,27(2):165-168. 被引量：10
  • 4Korst RJ, Crystal RG. Active, specific immunotherapy for lung cancer: hurdles and strategies using genetic modification. Ann Thorae Surg,2003 .76(4) : 1319-1326.
  • 5Moretta L, Moretta A. Unravelling natural killer cell function: triggering and inhibitory human NK receptors. EMBO J, 2004. 23(2) :255-259.
  • 6Groh V, Rhinehart R, Secrist H,et al. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proe Natl Acad Sci U S A,1999.96(5) :6879-6884.
  • 7Dickson BJ, Gilestro GF. Regulation of commissural axon pathfinding by slit and its Robo reeeptors. Annu Rev Cell Dev Biol, 2006 ; 22 : 651-675.
  • 8Armeanu S, Bitzer M, Lauer UM, et al. Natural killer cell- mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate. Cancer Res,2005;65(14):6321-6329.
  • 9Yamamoto K, Fujlyama Y, Andoh A, et al. Oxidative stress inereases MICA and MICE, gene expression in the human colon eareinoma eell line(CaCo-2). Bioehim Biophys Aeta,2001;1526 (1): 1012-1015.
  • 10Houehins JP, Yabe T, MeSherry C, et al. DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. J Exp Med, 1991 . 173(4), 1017-1020.

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国外医学（生理病理科学与临床分册）
2003年 第4期

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