1Wren AM, Small CJ, Abbott CR, et al. Ghrelin causes hyperphagiaand obesity in rats[ J]. Diabetes,2001, 50( 11 ) :2540-2547.
2Tsehop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents[ J]. Nature,2000 ,407 ( 19 ) :908-913.
3Hansen TK, Dall R, Hosoda H, et al. Weight loss increases cireulating levels of Ghrelin in human obesity [ J ]. Clin Endocrinol(oxf) ,2002,56(2) :203-206.
4Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach [ J ]. Nature, 1999,402(6762) : 656-660.
5Cummings DE, Pumell JQ, Frayo RS, et al. A preprandial rise in plasma Ghrelin levels suggests a role in meal initiation in humans[J]. Diabetes, 2001 ,50(8) : 1714-1719.
6Shintani M, Ogawa Y, Ebihara K, et al. Ghrelin, an Endogenous Growth Hormone Secretagogue, is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway [ J]i Diabetes, 2001, 50(2) :227-232.
7Kojima M, Hosoda H, Date Y ,et al. Ghrelin is a growth-hormonereleasing acylated peptide from stomach [ J]. Nature, 1999,402(6762) : 656-660.
8Janssen JA, van Der Toom FM, Holland LJ, et al. Systemic Ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy[ J ]. Eur J Endocrinol,2001,145 (6) :711-716.
9Horvath TL, Diano S, Sotonyi P, et al. Minireview: Ghrelin and the regulation of energy balance--a hypothalamic perspective [ J ].Endocrinology,2001,142(10) : 4163-4169.
10Shiiya T, Nakagato M, Mizuta M, et o2. Plasma Ghrelin levels in lean and obese humans and the effect of glucose on Ghrelin secretion[J]. J Clin Endocrinol Metab,2002, 87( 1 ) : 240-244.
