血压变异及左室肥厚是老年高血压发生心脑血管事件的危险因子

THE RELATIONSHIP BETWEEN LEFT VENTR ICLE HYPERTROPHY,BLOOD PRESSURE VARIATION AND CARDIO-CEREBROVASCU LAR EVENTS IN ELDERLY HYPERTENSION

目的探讨老年高血压病患者的昼夜动态血压变异程度及左室质量指数(LVMI)与心脑血管事件发生的关系。方法采集近年来因心脑血管疾病住院的老年高血压病患者共269例。年龄在65～87岁之间,均有身高、体重、心电图、血清胆固醇、二维心超、24小时动态血压及脑CT的检查资料,并将其分成心脑血管事件发生组(A组)与未发生组(B组)进行比较。结果269例中A组154例,B组115例,A组的LVMI与昼夜血压标准差(SD)均明显高于B组(P<0.01)。而血清胆固醇、心电图等一般情况与B组无显著差异。结论左室肥厚与血压变异呈正相关性,而血压变异程度又是独立并显著地与心脑血管事件有关系,并且随着血压变异增大,心脑血管事件的发生率同比增大,靶器官损害加重。

Objective To investigate the association betw een the 24h ambulatory blood pressur e(ABPM)variation,left ventricle mass index(LVMI )and the incidence of cardio -cerebro vascular events(CCV)in elderly hypertension.Methods We gathered 269cases who had been hospitalized because of cardio -cerebr ovascular diseases,aged between 65to 87years,containing the data of height,weigh t,EKG,serum cholesterol,echocard iogram,ABPM and brain CT.We divided the patients in two groups,with CCV in group A,wit hout CCV in group B.Results We get 154patients in group A,115patients in group B.The LVMI and standard deviation(SD)of 24h ABPM in group A were remarkable higher than group B(P<0.01),but the common conditions such as serum cholesterol,EKG,were without notable d ifferences in two groups.Conclusions Left ven-tricle hypertrophy(LVH)has a positive correlation with blood pressure variation(BPV).The BPV is an isolated notable facto r of the CCV incidence which rose according to the BPV increased.The CCV incidence raised proportionally and th e target organs impairment aggravated.[