颅内多发性海绵状血管瘤(附14例报告)

Multiple intracranial cavernous angiomas(14 cases report)

目的 研究颅内多发性海绵状血管瘤 (ICA)临床表现、诊断及治疗。方法 回顾性分析14例多发性ICA。结果 14例共 32个病灶 ,MRI检出 30个 ;表现为神经系统多个部位受损的症状和体征 ;12例共 18个病灶手术切除 ,其余病灶采用保守治疗 ;手术无死亡 ,疗效满意 ;14例中 5例有可能家族史。结论 多发性ICA的诊断主要依靠MRI检查 ;手术治疗是主要的方法 ;神经导航对于多发性ICA的手术有较高的应用价值 ;多发性ICA与家族性海绵状血管瘤 (FICA)关系密切。

Objective To study the clinical manifestation,diagnosis and management of multiple intracranial cavernous angiomas(ICA). Methods Total 14 patients of multiple ICA were analyzed retrospectively . Results There were 32 lesions occurred in 14 patients, 30 of them were checked out by MRI. Neural symptoms or signs due to damages of various brain sites were found.18 lesions of 12 patients were removed totally by operation , the rest were managed by medical treatment. No case died of the factors of operation, curative effect was satisfactory. 5 cases had presumed family history.Conclusion The diagnosis of multiple ICA relies on MRI. Surgical intervention is chief management. Neural navigation has much value of application to the surgery of multiple ICA.Multiple ICA is related to familial intracranial cavernous angiomas(FICA).