骨髓增生异常综合征细胞形态学观察

Analysis of dysmyelopoiesis in 49 patients with myelodysplastic syndrome(MDS)

目的 观察骨髓增生异常综合征 (MDS)骨髓细胞形态学病态改变。方法 用瑞氏 姬姆萨混合染液染色 ,进行骨髓及外周血细胞学分析。结果 粒、红、巨核三系都有不同程度的病态造血。粒系主要以细胞核浆发育不平衡 ,内外浆、中性粒细胞核分叶不能或Pelger Hu t样畸形。结论 MDS三系均有不同程度的病态改变 ,患者以中老年居多 ,分型主要以RA为主。

Objective To observe the morphologic abnormalities of bone marrow(BM)cells in MDS paitents.Methods Morphologic changes in peripheral blood and BM cells were observed by Wright Giemsa staining.Results Dysmyelopoiesis at different degrees was found in all paitents,including dyserythropoiesis,dysgranulomonopoiesis and dysmegakaryoctytopoiesis.The dysgranulopietic features were mainly characterized by nuclear cytoplasmic dissociation of maturation and hyposegmentation of the mucleus (pseudo Pelger Huetanomaly),while erythrocytes exhibited megaloblastoid maturation,muclear lobulation,flower like mucleus and karyorrhexis.Conclusion There exists trilineage dysplasia at different degrees in MDS,which chiefly affects middle and old aged people and expresses RA subtype most frequently.