胚胎干细胞移植心肌再生的研究进展
摘要
由心肌梗死、心力衰竭、心肌病等造成心肌细胞数量缺失,进而破坏心脏结构与功能,心肌细胞的不可再生性以及现有治疗手段均不能促使缺失心肌细胞数量恢复。而利用胚胎干细胞自我复制与全能分化特点,将其移植至宿主心脏以恢复心脏结构与功能,实验证实是可行的,但也存在一些问题,本文就这一研究领域的研究进展作一综述。
出处
《国外医学（老年医学分册）》
2003年第5期198-202,共5页
Foreign Medical Sciences(Geriatrics)
参考文献21
-
1Jakson KA, Goodie MA. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci USA,1999; 96 (12): 14482～14486.
-
2Gondorelli G, Borello U, Deangelis L et al. Cardiomyocytes induce endothelial cells to trans- differentiation into cardiac muscle: implication for myocardium regeneration. Proc Natl Acad Sci USA, 2001; 98 (8): 10733～10738.
-
3Reincke H, Poppa V, Muny CE et al, Skeletal, muscle stem do not trans- differentiate into cardiomyocytes after cardiac grafting. J Mol Cell Cardiol, 2002; 34 (2): 241-249.
-
4Orlic D, Hill JM, Arai AE. Stem cells for myocardial regeneration. Cir Res, 2002; 124 (3): 584～590.
-
5Bader A, Gruss A, Hollrigla A et al. Paracrine promotion of cardiomyogenesis in embryoid bodies by LIF modulated endoderm. Differentiation, 2001; 68 (1): 31～43.
-
6Guan K, Rohwedel J, Wobus AM. Embryonic stem cell differentiation models: cardiogenesis, myogenesis, neurogenesis,epithelial and vascular smooth muscle cell differentiation in vitro. Cytotechnology, 1999; 30 (1-3): 211～226.
-
7Beufar A, Zingman LV, Hedgson DW at al. Stem cell differentiation requires a paracrine pathway in the heart. FASEB,2002, 16 (12): 1558～1566.
-
8Chedrawy EG, Wang JS, Wobus, et al. Incorporation and integration of implanted myogenic and stem cells into native myocardial fibers: anatomic basis for functional improvement.J Thora Cardiovas Surg, 2002; 124 (3): 584～590.
-
9Kohei J, Li C, Akihiw S et al. Survival and function of mouse embryonic stem cell- derived cardiornyocytes in ectopic transplants. Cardiovas Res, 2003; 58 (2): 435.
-
10Yang YK, Min JY, Ke QG et al. Cardiogenesis and angiogenesis in infracted myocardium by intramyocardial transplantation of embryonic stem cells in mice. Circulation,2001; Supple Ⅰ : Ⅱ - 270.
-
1胚胎干细胞移植治糖尿病获进展[J].中老年保健,2003(3):43-43.
-
2陶章,李惠萍,陈学进,余慧,胡洋,姜寒水.胚胎干细胞移植对博来霉素所致小鼠肺损伤的治疗作用[J].中华器官移植杂志,2009,30(10):589-593. 被引量：2
-
3德利用胚胎干细胞治疗糖尿病获进展[J].保健医苑,2003(3):44-44.
-
4张昆南,吴晓牧.干细胞移植治疗与脑梗死[J].中华脑血管病杂志（电子版）,2010,4(4):1-2.
-
5褚丽东,曾庆华.干细胞移植治疗心肌梗死的研究进展[J].高校保健医学研究与实践,2007,4(1):74-80.
-
6沈正善,张学忠,徐燕丽.复方皂矾丸联合环孢菌素A治疗慢性再生障碍性贫血的研究[J].实用医技杂志,2004,11(12A):2503-2504. 被引量：1
-
7钱伟莉,杨新春,于丽萍,郭雷生,高飞,刘秀兰.胚胎干细胞移植到大鼠梗死心脏后的分化研究[J].中国心血管杂志,2010,15(2):130-133.
-
8孙玉.胚胎干细胞移植治疗效果研究[J].生物技术通报,2005,21(1):59-59.
-
9干细胞 心肌再生[J].首都医药,2004,11(10):10-10.
-
10杨志明.深入开展细胞治疗研究,加快临床应用步伐[J].中国修复重建外科杂志,2009,23(1):40-40.
