心肌缺血预适应对急性心肌梗塞的影响

Effects of Ischemic Preconditioning on Acute Myocardial Infarction

目的 :评价心肌缺血预适应对急性心肌梗塞患者梗塞范围及近期预后的影响。方法 :76例初发 AMI并接受住院治疗的患者 ,按梗塞前 4 8h有无心绞痛分为缺血预适应 (A)组 (n=4 4 )、无缺血预适应 (B)组 (n=32 ) ,对比两组患者的临床资料。结果 :A组比 B组的心肌梗塞范围小 (P<0 .0 5 ) ,血清心肌酶学峰值低 (P<0 .0 5 ) ,恶性心律失常、心力衰竭、心源性休克发生率及病死率均明显降低 (P<0 .0 5 )。结论 :心肌缺血预适应具有保护心肌、缩小梗塞范围 ,改善初梗患者近期预后的作用。

Objective:To evaluate the effects of ischemic preconditioning on first acute myocardial infarction(AMI). Methods:76 cases of first AMI during hospitalization were divided into two groups:ischemic precondition group (A,n=44)with angina 48 hours before AMI;no ischemic precondition group(B,n=32) without angina. The clinical data of the two groups were compared.Results:The infarction size was smaller in the group A than that in the group B(P<0.05).The peak value of myocardial enzyme was lower in group A than in group B(P<0.05),and the incidence of malignant arrhythmia, heart failure, cardiogenic shock and mortality were also lower in the group A than those in the group B(P<0.05).Conclusion:Ischemic preconditioning could protect myocardium and reduce the infarction size, improve the short-term prognosis of first AMI patients.