胰岛素样生长因子Ⅰ及一氧化氮检测对冠心病患者预后的影响

The effect of measuring insulin-like growth factor I and nitric oxide on prognosis in patients with coronary heart disease

目的:探讨胰岛素样生长因子(insulin-likegrowthfactorⅠ,IGFⅠ)在冠心病发病中的可能机制。方法:测定了16例正常人血清IGFⅠ、一氧化氮(nitricoxide,NO)水平以及40例冠心病患者血清IGFⅠ,NO水平,且把冠心病患者血清IGFⅠ,NO水平与冠状动脉造影的血管病变支数进行了比较分析。结果:冠心病患者血清IGFⅠ水平显著低于正常人,分别为(27.23±15.48)μg/L和(48.02±33.43)μg/L,(t=2.180,P<0.01);且在冠状动脉造影血管病变支数增加时其血清IGFⅠ水平下降变得更加明显。冠心病患者血清的NO水平也是显著低于正常人,分别为(63.00±10.01)mmol/L和(71.19±13.63)mmol/L,(t=2.937,P<0.05);且在冠状动脉血管病变支数增加时其血清NO水平下降变得更加明显。而血清IGFⅠ与NO水平间存在正相关(r=0.425,P<0.05)。结论:IGFⅠ可能参与了冠心病的病理生理过程,而其参与冠心病的机制可能通过影响NO来实现。

AIM:To investigate the probable mechani sm of insulin-l ike growth factor 1(IGFⅠ)in coronary heart disease.METHODS:The levels of I GFⅠand nitric oxide(NO)in 56patients who were diveded into two group(contr ol group,n=16;patients group,n=40)confirmed by coronary angiography we re measured.The relationship betw een the levels of IGFⅠ,NO and the number of narrow artery in coronary heart disease patients was analyzed.RESULTS:The lev els of IGFⅠin patients was lower than that in con trol group.(27.23± 15.48)μg /L and(48.02±33.43)μg /L,t=2.180,P<0. 01.The levels of IGFⅠgot much lower with the coronary angi ography numbers increased.The levels of NO i n patients with coronary heart disease were lower than control group(63.00±10.01)mmol /L and(71.19±13. 63)mmol /L,t=2.937,P<0.05respectively.The levels of IGFⅠand NO got much lower with the many narrow coronary artery numbers than one narrow coronary artery in the pat ients.There was positive relationship between serum IGFⅠand NO levels in the patients(r=0.425,P<0.05).CONCLUSION:IGFⅠmay take part in the pathophysiological process of coronary heart disease and to be realized by regulating NO metabolism.