巨细胞病毒感染与冠心病关系的临床研究

Clinical study of the relationship between human cytomegalovirus infection and coronary heart disease

目的 探讨人类巨细胞病毒 (HCMV)感染与冠心病的关系。方法 采用间接ELISA法检测其外周血巨细胞病毒抗体 ,同时应用免疫透射比浊法测定其C反应蛋白的水平。结果 冠心病组 6 0例 ,外周血巨细胞病毒抗体IgG阳性 2 6例 (4 3 3% ) ,健康对照组 6 0例中阳性 10例 (16 6 % ) ,两组比较差异有显著意义 (P <0 0 5 )。HCMV抗体阳性者 2 6例同时检测外周血CRP水平大于正常者 2 0例 (76 9% ) ,正常对照组2 6例CRP水平大于正常者 3例 (11 5 % ) ,两组比较差异有显著意义 (P <0 0 1)。结论 巨细胞病毒感染与冠心病之间关系密切。

Objective To investigate the relationship between human cytomegalovirus(CMV) infection and coronary heart disease(CHD).Methods The antibodies of human CMV were detected by indirect ELISA technique and the level of C reactive protein(CRP) by immunotubidimetric.Results In 60 patients with coronary heart disease 26 cases(43.3%) were considered as positive for CMV infection.In comparasion,positive band was detected in only 16.6%(10/60 cases) in healthy objectives.This difference of CMV infection between two groups was statistically significant(P<0.05).At the same time we assayed the CRP level of the 26 cases whose antibodies of human CMV were positive and 26 cases of healthy control.There were 20 cases(76.9%) whose CRP level were higher than that in the 26 cases whose CMV antibodies were positive.There were 3 cases(11.5%) whose CRP level were higher in 26 healthy controls.This difference between two groups was statistically significant(P<0.01).Conclusion CMV infection is related to coronary heart disease.