摘要
用标准的微量淋巴细胞毒试验、62种人白细胞抗原(HLA)抗血清调查了61例弥漫性甲状腺肿伴甲状腺机能亢进症(Graves病)病人的HLA-A、HLA-B和HLA-Cw抗原.Graves病组的HLA-Bw_(46)抗原发生率(49.18%)显著高于对照组(5.31%),相对危险率(RR)为17.903,相对危险率的显著性x^2值为19.240(P<0.0001).
We used standard microdroplet Iymphocytotsicity test employing 62 HLA antisera to investigate HLA-A, -B, -Gw antigen frequencies in 61 patients with Graves' disease. The frequency of HLA-Bw_(46) showed a significant increase in the group of Graves'disease (49.18%) compared to normal controls (5.31%). The relative risk (RR) for HLA-Bw_(46) was 17.903. The X^2 value was 19.240 (P<0.0001). These findings suggest a strong association between HLA-Bw_(46) and Graves' disease. The frequency of HLA-A_(24) antigen tended to decrease significantly in patients with Graves' disease as compared with controls, revealing a negative correlation.
出处
《青岛医学院学报》
1992年第2期111-113,共3页
Acta Academiae Medicinae Qingdao Universitatis