遗传性癫痫模型鼠与Ca^(2+)-ATP酶关系的研究

RESEARCHES ON RELATIONSHIP BETWEEN GENETICALLY AUDIOGENIC SEIZURE MICE AND THE Ca^(2+)-ATPase ACTIVITY

本研究分别观察了DBA/2J(简称D_2)和C_(57)B4/6(简称B_6)小鼠在噪声中癫痫样发作的诱发得分及脑干区Ca^(2+)-ATP酶的活性.结果发现,D_2组噪声诱发得分显著高于B_6组,而脑干区Ca^(2+)-ATP酶活性明显低于B_6组,D_2与B_6杂交后代的发作得分显著低于B_2,与B_6相似;Ca^(2+)-ATP酶活性介于D_2与B_6之间.说明癫痫样发作与遗传有关,其遗传方式符合多基因遗传.对D_2组内有癫痫样发作及无癫痫样发作小鼠Ca^(2+)-ATP酶活性的统计学处理表明两者差异有显著性.进一步证实Ca^(2+)-ATP酶对D_2小鼠的癫痫遗传易患性起决定性作用.

We investigated the seizure score and Ca^(2+)-ATPase activity in brain stem of two kinds audiogenic mice-DBA/2(D_2 ) and C_(57)/B_6 (B6). The results showed that the seizure score in D_2 is significantly higher than that of B_6,but the Ca^(2+)-ATPase activity of brain stem is much lewer in D_2 than in B_6. This suggests that the seizure in the audiogenic seizure mice is determined by inheritace, and the mode of inheritance is correlated with multifacterial inheritance. The statistic analysis showed that the Ca^(2+)-ATPase activity is significantly higher in the seizure mice of D_2 than in the non-seizure mice of D_2. That further confirmed that the activity of Ca^(2+)-ATPase plays a aesicive role in the inheritance of the seizur in audiogenic seizure mice.