中子辐射对小鼠血清总胆汁酸和葡萄糖影响的实验研究

The Experimental Study of the Neutron Irradiation Effects on the Blood TBA and Glucose in Mouse Models

目的 研究中子辐射对血清总胆汁酸 (TBA)和葡萄糖 (GLU)的影响。方法 采用二级BALB/C小鼠作为实验动物 ,用中子源对各动物组进行 2 5～ 5 .5Gy的照射。结果 2 5Gy照射组小鼠TBA于照后 6h开始明显升高 ,照后第 14d后逐渐下降。 3 0Gy～ 5 5Gy照射组小鼠TBA均显著高于对照组。在 2 5Gy和 3 0Gy照射组小鼠GLU于照后 12h降低 ,之后又恢复至正常水平。在 5 5Gy照射组小鼠GLU于照后 12h下降 ,在第 2天明显升高 ,与对照组差异有显著性。结论 中子辐射引起血清TBA升高 ;小剂量的中子辐射引起GLU下降 ;

Objective To study the biochemical effects of neutron irradiation on the BALB/C mice including blood total bile acid (TBA)and blood glucose(GLU).Methods All the 728 male mice were randomly assigned into 4 experimental groups and 1 control group.The animals then were irradiated by the 0～5.5 Gy of 90% neutron respectively.Results The serum TBA of 2.5 Gy irradiation group remarkably increased at 6 h after irradiation.On the 14 th day after irradiation the TBA decreased gradually.But until the 28 th day,the TBA concentration is still higher than that of the control group.The TBA levels in the 3.0～5.5 Gy groups remarkably increased after each dosage irradiation.In the 2.5,3.0 and 5.5 Gy irradiation groups,the serum glucose levels of mice decreased remarkably at 12 h after irradiation.On the second day,the GLU concentration elevated remarkably in the 5.5 Gy irradiation group.Conclusion The TBA concentration increased after the each dosage of neutron irradiation.The concentration of GLU decreased after small dosage neutron irradiation.Large dosage neutron irradiation can lead to GLU elevated in the blood.