6Chevalier T, Brisgand P, Douilard JY, et al. Randomized study of vinoredine and cisplatin versus vindesine and cis platin versus vinorelbine alone in advanced non-small cell lung cancer: results of a European multicenter trial inclu ding 612 patients[J]. J Clin Oncol 1994,12(2): 360.
7Paul A, Bunn PAJr, Kelly K. New chemotherapeutic a gents prolong survival and improve quality of life in non small cell lung cancer: a review of the literature and fu ture directions[J]. Clin Cancer Res,1998,4(5): 1087.
8Landonio G, Sartore Bianchi A, Giannetta L. Controversies in the management of brain metastases: the role of chemotherapy[J]. Forum (Genova), 2001,11(1): 59.
9Pujol JL von-Pawel J, Tumolo S, et al. Preliminary re sults of combined therapy with topotecan and carboplatin in advanced non-small-cell lung cancer[J]. Oncology, 2001,61 Suppl 1: 47.
10Stupp R, Bodmer A Duvoisin B, et al. Is cisplatin re quired for the treatment of non-small-cell lung cancer? Experience and preliminary results of a phase Ⅰ / Ⅱ trial with topotecan and vinorelbine[J]. Oncology. 2001, 61 Suppl 1: 35.
9WANG H K, MORROS- NATSCHKE S L, LEE K H. Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents [ J ]. Mde Res Rev, 1997,17 (4) : 367 - 425.
10HAHN S A , SCHMIEGEL W H. Recent discoveries in cancer genetics of exocrine pancreatic neoplasia[ J]. Digestion, 1998,59 (5) :493 - 501.