大剂量阿托品抢救急性有机磷农药中毒

Treatment of acute organophosphorus poisoning with large doses of atropine

目的 :探讨大剂量阿托品抢救急性有机磷农药中毒的疗效。方法 :急性有机磷农药中毒患者随机分为治疗组和对照组 ,每组依病情分为轻度、中度、重度患者 ,治疗组患者给予大剂量阿托品治疗 ,对照组患者给予常规剂量阿托品治疗。结果 :轻度患者死亡率治疗组和对照组相比无明显差异 ,治疗组中度及重度患者死亡率明显低于对照组重度患者死亡率。结论

Objective: It is to study the efficacy of treatment of acute organophosphorus insecticides (OP) poisoning with large doses of atropine. Methods: All patients were randomized to therapy group and control group, each group were then classified into three categories according to signs and symptoms mild?moderate?severe, patients in therapy group were treated with large doses of atropine, patients in control group were treated with normal doses of atropine as usually recommended. Results: There is no difference in the mortality rate of mild cases between two groups, the mortality rate of moderate and severe OP poisoning cases in therapy group is lower than that in control group. Conclusion: Large doses of atropine may reduce the mortality rate of moderate and severe OP poisoning cases.