广州市孕妇碘营养状况研究

Study on the nutritional status of iodine for pregnant women in Guangzhou

目的 了解广州市孕妇 (孕中、晚期 )碘营养状况。方法 用砷 -铈接触法测定尿碘 ,用放射免疫分析法 (RIA )测定血清甲状腺素 (T4 )、促甲状腺激素 (TSH )。结果 孕妇孕中期尿碘中位数为 2 4 9.3μg/ L ,<10 0μg/ L者占 4 .5 % ;孕晚期尿碘中位数为 2 4 1.2μg/ L ,<10 0μg/ L者占 12 .5 % ,两期尿碘值差异无显著意义 (P >0 .0 5 )。孕中期血清 T4 (15 7.0± 6 6 .4 ) nmol/ L ,在正常范围 (5 4～ 174 nm ol/ L )者占 5 8.2 % ,超过 174 nmol/ L者占38.8% ;孕晚期血清 T4 (12 4 .4± 5 9.4 ) nm ol/ L ,在正常范围者占 78.3% ,超过 174 nmol/ L者占 13.0 %。孕中期血清 TSH (中位数 3.9m U / L ) <5 m U / L者占 6 5 .7% ,>5 m U / L者占 34.3% ;孕晚期血清 TSH (中位数 6 .9m U / L ) <5 m U/ L者占 18.2 % ,>5 m U / L者占 81.8%。两期自身对照 TSH>5 m U / L与 <5 m U / L人数构成差异有非常显著意义 (P <0 .0 1)。结论 广州市孕妇碘营养状况良好 ;孕晚期血清 TSH>5 m U / L者 (81.8% )较多 ,与尿碘、T4 水平不一致 。

Objective To investigate the nutritional status of iodine for pregnant women in Guangzhou.Methods The urinary iodine was measured by spectrophotometer. Content of T 4,TSH in serum was determined by radioimmunoassay(RIA).Results The median of urinary iodine in mid pregnant and later pregnant women was 249.3 and 241.2 μg/L,respectively. The proportions with urinary iodine<100 μg/L in mid pregnant and later pregnant women were 4.5% and 12.5%,respectively. The average T 4 level in mid pregnant women was (157.0±66.4)nmol/L,58.2% of them were within 54~174 nmol/L(recommended rang)and 38.8% were above 174 nmol/L. The average T 4 level of later pregnant women was(124.4±59.4)nmol/L,78.3% of them were within 54~174 nmol/L and 13.0% were above 174 nmol/L. The proportion of TSH>5 mU/L in mid pregnant was 36.4% and in later pregnant was 81.8%(P<0.01).Conclusions The pregnant women in Guangzhou have good nutritional status of iodine. The proportion of TSH>5 mU/L in later pregnant women is high(81.8%).