Antiphospholipid syndrome：a survey of clinical characters in ten cases

Objective: To gain further understanding of the antiphospholipid syndrome(APS) . Methods : Analysing clinical and laboratory data on ten cases of APS. Results: Thrombocytopenia appeared in all cases.Venous thrombi of limbs appeared in five eases and neurological abnormalities in two cases. Renal impairments were found in three cases. One case manifested left renal venous thrombi and the other two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in one case. One of the ten cases was catastrophic APS(CAPS) presented as acute diffuse swelling, cyanosis, pain, ischemia and necrosis in fingers and limbs,recurrem shock, ascites, hepatic and respiratory dysfunction. Anticoagulams and corticosteroids could be effective for dealing with APS. It was critical to treat catastrophic APS with anticoagulants or plasmapheresis as early as possible. Conclusions: APS shows variable manifestations for good prognosis, but catastrophic APS has fatal risk. The main treatment for APS is the use of anticoagulams and immunosuppressives.

Objective: To gain further understanding of the antiphospholipid syndr ome(APS). Methods: Analysing clinical and laboratory data on ten cases of APS. R esults: Thrombocytopenia appeared in all cases. Venous thrombi of limbs appeared in five cases and neurological abnormalities in two cases. Renal impairments we re found in three cases. One case manifested left renal venous thrombi and the o ther two cases thrombotic microangiopathy. Budd-Chiari syndrome was found in on e case. One of the ten cases was catastrophic APS(CAPS) presented as acute diffus e swel ling,cyanosis,pain,ischemia and necrosis in fingers and limbs,recurrent shoc k,ascites,hepatic and respiratory dysfunction. Anticoagulants and corticosteroids could be effective for dealing with APS. It was critical to trea t catastrophic APS with anticoagulants or plasmapheresis as early as possible. C onclusions: APS shows variable manifestations for good prognosis,but catastroph ic APS has fatal risk. The main treatment for APS is the use of anticoagulants a nd immunosuppressives.