中药地肤子的三萜和皂苷成分研究

Triterpene and Saponins from Kochia scoparia

目的 :对中药地肤子Kochiascoparia的三萜和皂苷成分进行分离和鉴定。方法 :采用不同层析技术进行分离 ,用波谱及化学的方法确定化合物的结构。结果 :分离鉴定了 8个化合物 :齐墩果酸 3 O β D 吡喃木糖 (1→ 3) β D 吡喃葡萄糖醛酸苷 (Ⅰ ) ,3 O β D 吡喃木糖 (1→ 3) β D 吡喃葡萄糖醛酸 齐墩果酸 2 8 O β D 吡喃葡萄糖酯苷 (Ⅱ ) ,齐墩果酸 2 8 O β D 吡喃葡萄糖酯苷 (Ⅲ ) ,齐墩果酸 3 O [β D 吡喃葡萄糖 (1→ 2 ) β D 吡喃木糖 (1→ 3) ] β D 吡喃葡萄糖醛酸苷 (Ⅳ ) ,齐墩果酸 3 O β D 吡喃葡萄糖醛酸甲酯苷 (Ⅴ ) ,齐墩果酸 3 O β D 吡喃木糖 (1→ 3) β D 吡喃葡萄糖醛酸甲酯苷 (Ⅵ ) ,齐墩果酸 (Ⅶ ) ,豆甾醇 3 O β D 吡喃葡萄糖苷 (Ⅷ )。化合物Ⅲ。

AIM:To search for bioactive constituents from Kochia scoparia. METHOD AND RESULT:Eight compounds were isolated from the glycosidic fraction of the fruit of Kochia scoparia. Their structures were identified as 3-O-β-D-xylopyranoyl(1→3)-β-D-glucuronopyranosyl oleanolic acid(Ⅰ),3-O-β-D-xylopyranoyl(1→3)-β-D-glucuronopyranosyl-28-O-β-D-glucopyranosyl oleanolic acid(Ⅱ),28-O-β-D-glucopyranosyl oleanolic acid(Ⅲ),3-O-[β-D-glucopyranosyl(1→2)β-D-xylopyranosyl(1→3)]-β-D-glucuronopyranosyl oleanolic acid(Ⅳ),3-O-β-D-[6-O-methyl-glucuronopyranosyl] oleanolic acid(Ⅴ),3-O-β-D-xylopyranosyl(1→3)-[6-O-methyl-glucuronopyranosyl] oleanolic acid(Ⅵ),oleanolic acid(Ⅶ),and stigmastenol 3-O-β-D-glycopyranoside(Ⅷ) by using chemical and spectroscopic methods,respectively. CONCLUTION:Compounds Ⅲ,Ⅴ and Ⅷ were isolated from this plant for the first time.