摘要
报道了22℃±3℃和16℃±2℃水温条件下花鲈 (Lateolabraxjaponicus)多次口服复方新诺明在肌肉、血液、肝脏、肾脏4种组织中的残留及消除规律。药物在花鲈肌肉、血液、肝脏、肾脏中的残留用二氯甲烷提取 ,反相高效液相色谱法检测药物浓度 ,最低检测限可达0.01μg/mL,平均回收率为80%～90%。研究结果表明 :两种温度下 ,复方新诺明在花鲈体内的残留和消除情况差异明显 ,药物的吸收率及其在组织中的消除速度受温度影响较大 ,较高温度下吸收率高 (TMP)且消除速度较快。建议花鲈在22℃和16℃水温条件下口服复方新诺明的停药期应为32d和26d。
This article firstly reports the residual characteristics of Sulfamethoxazole(SMZ)and Trimethoprin(TMP),which are many thimes taken orally,in Lateolabrax japonicus at different temperature.The medicine was distilled by methylene chloride from muscle,blood,liver and kidney.The concentrations of medicament were determined by High Performance Liquid Chromatography,the average recoveries were80%～90%and the limit of determination was0.01μg/mL.The results indicated that the speed of elimination changed at different water temperature.The withˉholding period for Lateoˉlabrax japonicus after oral administration at dose of150mg/kg with mixture of SMZ and TMP(5∶1)for5consecutive days should be26day and30day at water temperature22℃and16℃.
出处
《海洋科学》
CAS
CSCD
北大核心
2003年第9期16-20,共5页
Marine Sciences
基金
农业部重点科研项目渔95 B 00 01 02号
教育部海水养殖重点开放实验室200211号资助
关键词
复方新诺明
花鲈
残留
消除规律
Sulfamethoxazole(SMZ),Residues,Elimination,Lateolabrax japonicus
