抗癌药物8-氮鸟嘌呤在石墨电极上的电化学性质及电分析方法研究

The Electrochemical Study of Anticancer Drug 8-Azayuanine on Graphite Electrode and Its Analytical Application

研究了抗癌药物8-氮鸟嘌呤(8-AG)在浸蜡石墨电极上的电化学反应。在HAc-NaAc(pH3.6)缓冲溶液中,8-AG在浸蜡石墨电极上产生一受扩散控制的氧化波,峰电位为1.2V(vs.SCE),峰电流与8-AG浓度在8×10-7～1×10-4mol/L范围内有良好的线性关系,检出限为5×10-7mol/L。研究了电极反应过程,求得了对应的动力学参数,建立了灵敏、快速的8-AG的检测方法。

In this paper, the electrochemistry behavior of the anticancer drug 8azagunine (8AG) at waximmersed graphite electrode has been studied. In the HAcNaAc (pH 3.6) buffer, one diffusiondriven oxidation peak of 8AG is obtained with the peak potential of 1.2V (vs. SCE). The peak currents are linear to the 8AG concentration in the range of 8.0×10-7～1.0×10-4 mol/L, and the detection limit is 5.0×10-7 mol/L. The electrode reaction process has been investigated with several electrochemical techniques, and its dynamics parameters has been obtained.